EC - 3,5-dihydroxybiphenyl synthase

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IntEnz Enzyme Nomenclature


Accepted name:
3,5-dihydroxybiphenyl synthase
Other names:
biphenyl synthase [ambiguous]
Systematic name:
malonyl-CoA:benzoyl-CoA malonyltransferase



A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC, benzophenone synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033815
CAS Registry Number: 1217551-24-0


  1. Liu, B., Beuerle, T., Klundt, T. and Beerhues, L.
    Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
    Planta 218 : 492-496 (2004). [PMID: 14595561]
  2. Liu, B., Raeth, T., Beuerle, T., Beerhues, L.
    Biphenyl synthase, a novel type III polyketide synthase.
    Planta 225 : 1495-1503 (2007). [PMID: 17109150]

[EC created 2006, modified 2012]