EC 2.3.1.175 - Deacetylcephalosporin-C acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.175

Names

Accepted name:
deacetylcephalosporin-C acetyltransferase
Other names:
acetyl-CoA:deacetylcephalosporin-C acetyltransferase
DAC acetyltransferase
cefG
deacetylcephalosporin C acetyltransferase
acetyl coenzyme A:DAC acetyltransferase
acetyl-CoA:DAC acetyltransferase
CPC acetylhydrolase
acetyl-CoA:DAC O-acetyltransferase
DAC-AT
Systematic name:
acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase

Reaction

Comments:

This enzyme catalyses the final step in the biosynthesis of cephalosporin C.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033813
UniProtKB/Swiss-Prot:

References

  1. Matsuyama, K., Matsumoto, H., Matsuda, A., Sugiura, H., Komatsu, K. and Ichikawa, S.
    Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum.
    Biosci. Biotechnol. Biochem. 56: 1410-1412 (1992). [PMID: 1368946]
  2. Gutiérrez, S., Velasco, J., Fernandez, F.J. and Martín, J.F.
    The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase.
    J. Bacteriol. 174: 3056-3064 (1992). [PMID: 1569032]
  3. Matsuda, A., Sugiura, H., Matsuyama, K., Matsumoto, H., Ichikawa, S. and Komatsu, K.
    Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C O-acetyltransferase from Acremonium chrysogenum.
    Biochem. Biophys. Res. Commun. 186: 40-46 (1992). [PMID: 1632779]
  4. Gutiérrez, S., Velasco, J., Marcos, A.T., Fernández, F.J., Fierro, F., Barredo, J.L., Díez, B. and Martín, J.F.
    Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum.
    Appl. Microbiol. Biotechnol. 48: 606-614 (1997). [PMID: 9421924]
  5. Velasco, J., Gutiérrez, S., Campoy, S. and Martín, J.F.
    Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits.
    Biochem. J. 337: 379-385 (1999). [PMID: 9895280]
  6. Martín, J.F., Gutiérrez, S., Fernández, F.J., Velasco, J., Fierro, F., Marcos, A.T. and Kosalkova, K.
    Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.
    Antonie Van Leeuwenhoek 65: 227-243 (1994). [PMID: 7847890]

[EC 2.3.1.175 created 2005]