EC 2.3.1.169 - CO-methylating acetyl-CoA synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.169

Names

Accepted name:
CO-methylating acetyl-CoA synthase
Other name:
ACS
Systematic name:
acetyl-CoA:corrinoid protein O-acetyltransferase

Reaction

Cofactors

Comments:

Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043884
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Ragsdale, S.W. and Wood, H.G.
    Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
    J. Biol. Chem. 260 : 3970-3977 (1985). [PMID: 2984190]
  2. Doukov, T.I., Iverson, T., Seravalli, J., Ragsdale, S.W. and Drennan, C.L.
    A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
    Science 298 : 567-572 (2002). [PMID: 12386327]

[EC 2.3.1.169 created 2003, modified 2015]