EC 2.3.1.166 - 2α-hydroxytaxane 2-O-benzoyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.3.1.166

Names

Accepted name:
2α-hydroxytaxane 2-O-benzoyltransferase
Other name:
benzoyl-CoA:taxane 2α-O-benzoyltransferase
Systematic name:
benzoyl-CoA:taxan-2α-ol O-benzoyltransferase

Reaction

Comments:

The enzyme was studied using the semisynthetic substrate 2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the hydroxy group at 1β, 7β, 10β or 13α of 10-deacetylbaccatin III, or at 2α or 5α of taxa-4(20),11-diene-2α,5α-diol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050642
CAS Registry Number: 329318-50-5
UniProtKB/Swiss-Prot:

References

  1. Walker, K. and Croteau, R.
    Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli.
    Proc. Natl. Acad. Sci. USA 97 : 13591-13596 (2000). [PMID: 11095755]

[EC 2.3.1.166 created 2002]