EC - 6-methylsalicylic acid synthase

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IntEnz Enzyme Nomenclature


Accepted name:
6-methylsalicylic acid synthase
Other names:
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)



A multienzyme complex with a 4'-phosphopantetheine prosthetic group on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050641
CAS Registry Number: 9045-37-8


  1. Spencer, J.B. and Jordan, P.M.
    Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.
    Biochem. J. 288: 839-846 (1992). [PMID: 1471999]
  2. Child, C.J., Spencer, J.B., Bhogal, P. and Shoolingin-Jordan, P.M.
    Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies.
    Biochemistry 35: 12267-12274 (1996). [PMID: 8823160]
  3. Richardson, M.T., Pohl, N.L., Kealey, J.T. and Khosla, C.
    Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase.
    Metab. Eng. 1: 180-187 (1999). [PMID: 10935930]

[EC created 2002]