EC - Isopenicillin-N N-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
isopenicillin-N N-acyltransferase
Other names:
acyl-coenzyme A:isopenicillin N acyltransferase
isopenicillin N:acyl-CoA acyltransferase
Systematic name:
acyl-CoA:isopenicillin N N-acyltransferase



Proceeds by a two-stage mechanism via 6-aminopenicillanic acid. Different from EC, penicillin amidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102920 , GO:0050640
CAS Registry Number: 54576-90-8


  1. Tobin, M.B., Fleming, M.D., Skatrud, P.L. and Miller, J.R.
    Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli.
    J. Bacteriol. 172 : 5908-5914 (1990). [PMID: 2120195]
  2. Aplin, R.T., Baldwin, J.E., Roach, P.L., Robinson, C.V. and Schofield, C.J.
    Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
    Biochem. J. 294 : 357-363 (1993). [PMID: 8396910]

[EC created 2002]