EC 2.3.1.162 - Taxadien-5α-ol O-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.162

Names

Accepted name:
taxadien-5α-ol O-acetyltransferase
Other names:
taxadienol acetyltransferase
taxa-4(20),11(12)-dien-5α-ol O-acetyltransferase
acetyl coenzyme A:taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase
Systematic name:
acetyl-CoA:taxa-4(20),11-dien-5α-ol O-acetyltransferase

Reaction

Comments:

This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050638
CAS Registry Number: 229032-29-5
UniProtKB/Swiss-Prot:

References

  1. Walker, K., Ketchum, R.E., Hezari, M., Gatfield, D., Goleniowski, M., Barthol, A. and Croteau, R.
    Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis.
    Arch. Biochem. Biophys. 364: 273-279 (1999). [PMID: 10190984]
  2. Walker, K., Schoendorf, A., Croteau, R.
    Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.
    Arch. Biochem. Biophys. 374: 371-380 (2000). [PMID: 10666320]

[EC 2.3.1.162 created 2002]