EC 2 - Transferases
EC 2.3 - Acyltransferases
EC 2.3.1 - Transferring groups other than amino-acyl groups
EC 2.3.1.16 - Acetyl-CoA C-acyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.3.1.16
Names
Accepted name:
acetyl-CoA C-acyltransferase
Other
names:
3-ketoacyl CoA thiolase
3-ketoacyl coenzyme A thiolase
3-ketoacyl thiolase
3-ketoacyl-CoA thiolase
3-ketothiolase
3-oxoacyl-CoA thiolase
3-oxoacyl-coenzyme A thiolase
6-oxoacyl-CoA thiolase
β-ketoacyl coenzyme A thiolase
β-ketoacyl-CoA thiolase
β-ketoadipyl coenzyme A thiolase
β-ketoadipyl-CoA thiolase
β-ketothiolase
KAT
acetoacetyl-CoA β-ketothiolase
acetyl-CoA acyltransferase
ketoacyl-CoA acyltransferase
ketoacyl-coenzyme A thiolase
long-chain 3-oxoacyl-CoA thiolase
oxoacyl-coenzyme A thiolase
pro-3-ketoacyl-CoA thiolase
thiolase I
2-methylacetoacetyl-CoA thiolase
3-ketoacyl coenzyme A thiolase
3-ketoacyl thiolase
3-ketoacyl-CoA thiolase
3-ketothiolase
3-oxoacyl-CoA thiolase
3-oxoacyl-coenzyme A thiolase
6-oxoacyl-CoA thiolase
β-ketoacyl coenzyme A thiolase
β-ketoacyl-CoA thiolase
β-ketoadipyl coenzyme A thiolase
β-ketoadipyl-CoA thiolase
β-ketothiolase
KAT
acetoacetyl-CoA β-ketothiolase
acetyl-CoA acyltransferase
ketoacyl-CoA acyltransferase
ketoacyl-coenzyme A thiolase
long-chain 3-oxoacyl-CoA thiolase
oxoacyl-coenzyme A thiolase
pro-3-ketoacyl-CoA thiolase
thiolase I
2-methylacetoacetyl-CoA thiolase
Systematic name:
acyl-CoA:acetyl-CoA C-acyltransferase
Reactions
- (1) acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
- (1a) acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine
- (1b) acyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine = acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + CoA
Comments:
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid β-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9.
Links to other databases
Protein domains and families:
PROSITE:PDOC00092
Gene Ontology:
GO:0003988
CAS Registry Number:
9029-97-4
References
-
A synthesis of dl-cortisone acetate.J. Am. Chem. Soc. 75 : 4111-4112 (1953).
-
Studies on the fatty acid oxidizing system of animal tissue. VII. The β-ketoacyl coenzyme A cleavage enzyme.J. Biol. Chem. 208 : 345-357 (1954). [PMID: 13174544]
-
Enzymatic breakdown and synthesis of acetoacetate.Nature 171 : 28-30 (1953).
[EC 2.3.1.16 created 1961]