EC - Phloroisovalerophenone synthase

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IntEnz Enzyme Nomenclature


Accepted name:
phloroisovalerophenone synthase
Other names:
3-methyl-1-(trihydroxyphenyl)butan-1-one synthase
valerophenone synthase
Systematic name:
isovaleryl-CoA:malonyl-CoA acyltransferase



Closely related to EC, naringenin-chalcone synthase. The product, 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one, is phloroisovalerophenone. Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone. The products are intermediates in the biosynthesis of the bitter (α) acids in hops (Humulus lupulus).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00403
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050634


  1. Fung, S.Y., Zuurbier, K.W.M., Paniego, N.B., Scheffer, J.J.C. and Verpoorte, R.
    Enzymes from the biosynthesis of hop α and β acids.
    Proc. 26th Congr. Eur. Brew. Conv. 215-221 (1997).
  2. Zuurbier, K.W.M., Leser, J., Berger, T., Hofte, A.J.P.,Schroder, G., Verpoorte, R. and Schroder, J.
    4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates.
    Phytochemistry 49 : 1945-1951 (1998).

[EC created 2000]