EC 2.3.1.150 - Salutaridinol 7-O-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.150

Names

Accepted name:
salutaridinol 7-O-acetyltransferase
Systematic name:
acetyl-CoA:salutaridinol 7-O-acetyltransferase

Reaction

Comments:

The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4→5 oxide bridge by allylic elimination to form the morphine precursor thebaine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047180
CAS Registry Number: 156859-13-1
UniProtKB/Swiss-Prot:

References

  1. Lenz, R., Zenk, M.H.
    Closure of the oxide bridge in morphine biosynthesis.
    Tetrahedron Lett. 35 : 3897-3900 (1994).
  2. Lenz, R., Zenk, M.H
    Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis.
    J. Biol. Chem. 270 : 31091-31096 (1995).

[EC 2.3.1.150 created 1999]