EC 2.3.1.147 - Glycerophospholipid arachidonoyl-transferase (CoA-independent)

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.3.1.147

Names

Accepted name:
glycerophospholipid arachidonoyl-transferase (CoA-independent)
Other name:
1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)
Systematic name:
1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)

Reaction

Comments:

Catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047177
CAS Registry Number: 102347-79-5

References

  1. Robinson, M., Blank, M.L., Snyder, F.
    Acylation of lysophospholipids by rabbit alveolar macrophages. Specific CoA-dependent and CoA-independent reactions.
    J. Biol. Chem. 260: 7889-7895 (1985). [PMID: 4008481]
  2. Snyder, F., Lee, T.C., Blank, M.L.
    The role of transacylases in the metabolism of arachidonate and platelet-activating factor.
    Prog. Lipid Res. 31: 65-86 (1992). [PMID: 1641397]

[EC 2.3.1.147 created 1999]