EC 2.2.1.8 - Fluorothreonine transaldolase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.2.1.8

Names

Accepted name:
fluorothreonine transaldolase
Systematic name:
fluoroacetaldehyde:L-threonine aldehydetransferase

Reaction

Cofactor

Comments:

A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into 4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033806
UniProtKB/Swiss-Prot:

References

  1. Murphy, C.D., O'Hagan, D. and Schaffrath, C.
    Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya.
    Angew. Chem. Int. Ed. Engl. 40: 4479-4481 (2001). [PMID: 12404452]
  2. Murphy, C.D., Schaffrath, C. and O'Hagan, D.
    Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.
    Chemosphere 52: 455-461 (2003). [PMID: 12738270]

[EC 2.2.1.8 created 2003]