EC 2 - Transferases
EC 2.2 - Transferring aldehyde or ketonic groups
EC 2.2.1 - Transketolases and transaldolases
EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.2.1.7
Names
Accepted name:
1-deoxy-D-xylulose-5-phosphate synthase
Other
names:
1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
DXP-synthase
1-deoxyxylulose-5-phosphate synthase
DXP-synthase
1-deoxyxylulose-5-phosphate synthase
Systematic name:
pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)
Reaction
- pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2
Cofactor
Comments:
Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00635
Gene Ontology:
GO:0008661
DXS1-2_ORYSJ
DXS1_CERS4
DXS1_GEOMG
DXS1_GEOSL
DXS1_JANSC
DXS1_KITGR
DXS1_ORYSJ
DXS1_RHORT
DXS1_ROSDO
DXS1_STRAW
DXS1_STRCO
DXS1_ZYMMO
DXS2_CERS4
DXS2_GEOMG
DXS2_GEOSL
DXS2_JANSC
DXS2_KITGR
DXS2_ORYSJ
DXS2_RHORT
DXS2_ROSDO
DXS2_STRAW
DXS2_STRCO
DXS2_ZYMMO
DXS_ACAM1
DXS_ACIAC
DXS_ACIAD
DXS_ACIBS
DXS_ACIBY
DXS_ACIC5
DXS_ACIET
DXS_ACISJ
DXS_ACTP2
DXS_ACTP7
DXS_ACTPJ
DXS_AERHH
DXS_AERS4
DXS_AGRFC
DXS_AGRRK
DXS_AGRVS
DXS_ALCBS
DXS_ALIB4
DXS_ALIF1
DXS_ALIFM
DXS_ALISL
DXS_ALKEH
DXS_ALKHC
DXS_ALKOO
DXS_ALTMD
DXS_ANAD2
DXS_ANADE
DXS_ANADF
DXS_ANASK
DXS_AQUAE
DXS_ARATH
DXS_AROAE
DXS_ARTS2
DXS_AZOC5
DXS_AZOPC
DXS_AZOSB
DXS_BACAA
DXS_BACAC
DXS_BACAN
DXS_BACC0
DXS_BACC1
DXS_BACC2
DXS_BACC4
DXS_BACC7
DXS_BACCN
DXS_BACCR
DXS_BACCZ
DXS_BACFN
DXS_BACFR
DXS_BACHK
DXS_BACLD
DXS_BACMK
DXS_BACP2
DXS_BACSK
DXS_BACSU
DXS_BACTN
DXS_BACVZ
DXS_BARBK
DXS_BARHE
DXS_BARQU
DXS_BART1
DXS_BAUCH
DXS_BEII9
DXS_BLOFL
DXS_BLOPB
DXS_BORA1
DXS_BORBR
DXS_BORPA
DXS_BORPD
DXS_BORPE
DXS_BRADU
DXS_BRASB
DXS_BRASO
DXS_BREBN
DXS_BRUA1
DXS_BRUA2
DXS_BRUA4
DXS_BRUAB
DXS_BRUC2
DXS_BRUMB
DXS_BRUME
DXS_BRUO2
DXS_BRUSI
DXS_BRUSU
DXS_BUCA5
DXS_BUCAI
DXS_BUCAP
DXS_BUCAT
DXS_BURA4
DXS_BURCA
DXS_BURCC
DXS_BURCH
DXS_BURCJ
DXS_BURCM
DXS_BURL3
DXS_BURMA
DXS_BURP0
DXS_BURP1
DXS_BURP6
DXS_BURPS
DXS_BURTA
DXS_CALS4
DXS_CAMFF
DXS_CAMHC
DXS_CAMJ8
DXS_CAMJD
DXS_CAMJE
DXS_CAMJJ
DXS_CAMJR
DXS_CAPAN
DXS_CARHZ
DXS_CAUSK
DXS_CAUVC
DXS_CAUVN
DXS_CELJU
DXS_CHESB
DXS_CHLAB
DXS_CHLCV
DXS_CHLFF
DXS_CHLL3
DXS_CHLMU
DXS_CHLPM
DXS_CHLPN
DXS_CHLT2
DXS_CHLTA
DXS_CHLTB
DXS_CHLTE
DXS_CHLTR
DXS_CHRSD
DXS_CHRVO
DXS_CITK8
DXS_CLAMS
DXS_CLOAB
DXS_CLOB8
DXS_CLOBA
DXS_CLOBB
DXS_CLOD6
DXS_CLOK1
DXS_CLOK5
DXS_CLONN
DXS_CLOP1
DXS_CLOPE
DXS_CLOPS
DXS_CLOTE
DXS_COLP3
DXS_CORDI
DXS_COREF
DXS_CORGB
DXS_CORGL
DXS_CORJK
DXS_CROS5
DXS_CROS8
DXS_CUPMC
DXS_CUPNH
DXS_CUPPJ
DXS_CUPTR
DXS_CUTAK
DXS_CYAP4
DXS_CYTH3
DXS_DECAR
DXS_DEHM1
DXS_DEHMB
DXS_DEHMC
DXS_DEIGD
DXS_DEIRA
DXS_DESAG
DXS_DESAP
DXS_DESHD
DXS_DESHY
DXS_DESPS
DXS_DESVH
DXS_DESVV
DXS_DICT6
DXS_DICTD
DXS_ECO24
DXS_ECO27
DXS_ECO45
DXS_ECO55
DXS_ECO57
DXS_ECO5E
DXS_ECO7I
DXS_ECO81
DXS_ECO8A
DXS_ECOBW
DXS_ECODH
DXS_ECOHS
DXS_ECOK1
DXS_ECOL5
DXS_ECOL6
DXS_ECOLC
DXS_ECOLI
DXS_ECOLU
DXS_ECOSE
DXS_ECOSM
DXS_ECOUT
DXS_EDWI9
DXS_ENT38
DXS_ERWT9
DXS_ERYLH
DXS_ESCF3
DXS_EXIS2
DXS_FRACC
DXS_FRAP2
DXS_FRASN
DXS_FRAT1
DXS_FRATF
DXS_FRATH
DXS_FRATM
DXS_FRATN
DXS_FRATO
DXS_FRATT
DXS_FRATW
DXS_FUSNN
DXS_GEOKA
DXS_GEOSW
DXS_GEOTN
DXS_GLOC7
DXS_GLOVI
DXS_GLUOX
DXS_HAEDU
DXS_HAEI8
DXS_HAEIE
DXS_HAEIG
DXS_HAEIN
DXS_HAEPS
DXS_HAES1
DXS_HAHCH
DXS_HALOH
DXS_HAMD5
DXS_HELHP
DXS_HELMI
DXS_HELPG
DXS_HELPH
DXS_HELPJ
DXS_HELPY
DXS_HISS2
DXS_HYPNA
DXS_IDILO
DXS_KLEP3
DXS_KLEP7
DXS_KOCRD
DXS_LACP7
DXS_LARHH
DXS_LAWIP
DXS_LEIXX
DXS_LEPBJ
DXS_LEPBL
DXS_LEPCP
DXS_LEPIC
DXS_LEPIN
DXS_LISIN
DXS_LISMC
DXS_LISMF
DXS_LISMO
DXS_LISW6
DXS_LYSSC
DXS_MACCJ
DXS_MAGMM
DXS_MAGSA
DXS_MANSM
DXS_MARMM
DXS_MARMS
DXS_METCA
DXS_METFK
DXS_METI4
DXS_METPP
DXS_MICAN
DXS_MOOTA
DXS_MYCA1
DXS_MYCA9
DXS_MYCBO
DXS_MYCBP
DXS_MYCBT
DXS_MYCGI
DXS_MYCLB
DXS_MYCLE
DXS_MYCPA
DXS_MYCPE
DXS_MYCS2
DXS_MYCSJ
DXS_MYCSK
DXS_MYCSS
DXS_MYCTA
DXS_MYCTO
DXS_MYCTU
DXS_MYCUA
DXS_MYCVP
DXS_MYXXD
DXS_NATTJ
DXS_NEIG1
DXS_NEIG2
DXS_NEIM0
DXS_NEIMA
DXS_NEIMB
DXS_NEIMF
DXS_NITEC
DXS_NITEU
DXS_NITHX
DXS_NITMU
DXS_NITOC
DXS_NITSB
DXS_NITWN
DXS_NOCFA
DXS_NOCSJ
DXS_NOSP7
DXS_NOSS1
DXS_NOVAD
DXS_PAEAT
DXS_PARD8
DXS_PARMW
DXS_PARP8
DXS_PARUW
DXS_PARXL
DXS_PASMU
DXS_PECAS
DXS_PECCP
DXS_PELTS
DXS_PELUB
DXS_PHEZH
DXS_PHOLL
DXS_PHOPR
DXS_PHOV8
DXS_POLNA
DXS_POLSJ
DXS_PORG3
DXS_PORGI
DXS_PROM0
DXS_PROM1
DXS_PROM2
DXS_PROM3
DXS_PROM4
DXS_PROM5
DXS_PROM9
DXS_PROMA
DXS_PROMH
DXS_PROMM
DXS_PROMP
DXS_PROMS
DXS_PROMT
DXS_PSE14
DXS_PSEA6
DXS_PSEA7
DXS_PSEA8
DXS_PSEAB
DXS_PSEAE
DXS_PSECP
DXS_PSEE4
DXS_PSEF5
DXS_PSEFS
DXS_PSEMY
DXS_PSEP1
DXS_PSEPF
DXS_PSEPG
DXS_PSEPK
DXS_PSEPW
DXS_PSESM
DXS_PSET1
DXS_PSEU2
DXS_PSEU5
DXS_PSYA2
DXS_PSYCK
DXS_PSYIN
DXS_RALPJ
DXS_RALSO
DXS_RENSM
DXS_RHIE6
DXS_RHIEC
DXS_RHIL3
DXS_RHILO
DXS_RHILW
DXS_RHIME
DXS_RHOBA
DXS_RHOCA
DXS_RHOCS
DXS_RHOE4
DXS_RHOFT
DXS_RHOJR
DXS_RHOP2
DXS_RHOP5
DXS_RHOPA
DXS_RHOPB
DXS_RHOPS
DXS_RHOPT
DXS_RIPO1
DXS_RUEPO
DXS_RUEST
DXS_SACD2
DXS_SACEN
DXS_SALA4
DXS_SALAR
DXS_SALCH
DXS_SALDC
DXS_SALEP
DXS_SALG2
DXS_SALHS
DXS_SALNS
DXS_SALPA
DXS_SALPB
DXS_SALPC
DXS_SALPK
DXS_SALSV
DXS_SALTI
DXS_SALTY
DXS_SERP5
DXS_SHEAM
DXS_SHEB2
DXS_SHEB5
DXS_SHEB8
DXS_SHEB9
DXS_SHEDO
DXS_SHEFN
DXS_SHEHH
DXS_SHELP
DXS_SHEON
DXS_SHEPA
DXS_SHEPC
DXS_SHEPW
DXS_SHESA
DXS_SHESH
DXS_SHESM
DXS_SHESR
DXS_SHESW
DXS_SHEWM
DXS_SHIB3
DXS_SHIBS
DXS_SHIDS
DXS_SHIFL
DXS_SHISS
DXS_SODGM
DXS_SPHAL
DXS_SPHWW
DXS_STRC1
DXS_STRGG
DXS_STRMK
DXS_SULDN
DXS_SYMTH
DXS_SYNAS
DXS_SYNC1
DXS_SYNE7
DXS_SYNJA
DXS_SYNJB
DXS_SYNP2
DXS_SYNP6
DXS_SYNPW
DXS_SYNR3
DXS_SYNS3
DXS_SYNS9
DXS_SYNSC
DXS_SYNWW
DXS_SYNY3
DXS_THEFY
DXS_THEMA
DXS_THEP1
DXS_THERP
DXS_THESQ
DXS_THET2
DXS_THET8
DXS_THEVB
DXS_THIDA
DXS_THISH
DXS_TREDE
DXS_TREPA
DXS_TREPS
DXS_TRIEI
DXS_TRIV2
DXS_TROW8
DXS_TROWT
DXS_VEREI
DXS_VIBA3
DXS_VIBC3
DXS_VIBCB
DXS_VIBCH
DXS_VIBCM
DXS_VIBPA
DXS_VIBVU
DXS_VIBVY
DXS_WIGBR
DXS_WOLSU
DXS_XANAC
DXS_XANC5
DXS_XANC8
DXS_XANCP
DXS_XANOM
DXS_XANOP
DXS_XANOR
DXS_XANP2
DXS_XYLF2
DXS_XYLFA
DXS_XYLFM
DXS_XYLFT
DXS_YERE8
DXS_YERP3
DXS_YERPA
DXS_YERPB
DXS_YERPE
DXS_YERPG
DXS_YERPN
DXS_YERPP
DXS_YERPS
DXS_YERPY
References
-
Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley,Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.Proc. Natl. Acad. Sci. USA 94 : 12857-12862 (1997). [PMID: 9371765]
-
Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H.Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis.J. Bacteriol. 182 : 891-897 (2000). [PMID: 10648511]
[EC 2.2.1.7 created 2001 as EC 4.1.3.37, transferred 2002 to EC 2.2.1.7]