EC 126.96.36.199 - Acetolactate synthase
IntEnz Enzyme Nomenclature
acetohydroxy acid synthetase
acetolactate pyruvate-lyase (carboxylating)
- 2 pyruvate = 2-acetolactate + CO2
This enzyme requires thiamine diphosphate. The reaction shown is in the pathway of biosynthesis of valine; the enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
Links to other databases
Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium.Biochim. Biophys. Acta 92 : 142-149 (1964).
The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure.Eur. J. Biochem. 20 : 209-214 (1971). [PMID: 5560406]
The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties.Eur. J. Biochem. 10 : 251-260 (1969). [PMID: 5823101]
Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria.J. Bacteriol. 169 : 3750-3756 (1987). [PMID: 3301814]
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.J. Biol. Chem. 279 : 2242-2253 (2004). [PMID: 14557277]
[EC 188.8.131.52 created 1972 as EC 184.108.40.206, transferred 2002 to EC 220.127.116.11]