IntEnz

EC 2.2.1.11 - 6-deoxy-5-ketofructose 1-phosphate synthase

IntEnz Enzyme Nomenclature
EC 2.2.1.11

Names

Reactions

• 31911 [IUBMB]
  β-D-fructose 1,6-bisphosphate

  beta-D-fructose 1,6-bisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:32966

  Formula: C6H10O12P2
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  methylglyoxal

  methylglyoxal

  Name origin: UniProt - CHECKED (C)

  CHEBI:17158

  Formula: C3H4O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

  1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58861

  Formula: C6H9O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-glyceraldehyde 3-phosphate

  D-glyceraldehyde 3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:59776

  Formula: C3H5O6P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  
• 32259 [IUBMB]
  β-D-fructose 1-phosphate

  beta-D-fructose 1-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:138881

  Formula: C6H11O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  methylglyoxal

  methylglyoxal

  Name origin: UniProt - CHECKED (C)

  CHEBI:17158

  Formula: C3H4O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

  1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58861

  Formula: C6H9O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-glyceraldehyde

  D-glyceraldehyde

  Name origin: UniProt - CHECKED (C)

  CHEBI:17378

  Formula: C3H6O3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.

Links to other databases

References

1. White, R. H., Xu, H.
   Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
   Biochemistry 45: 12366-12379 (2006). [PMID: 17014089]
2. Samland, A. K., Wang, M., Sprenger, G. A.
   MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
   FEMS Microbiol. Lett. 281: 36-41 (2008). [PMID: 18318840]

[EC 2.2.1.11 created 2012]