EC 2 - Transferases
EC 2.2 - Transferring aldehyde or ketonic groups
EC 2.2.1 - Transketolases and transaldolases
EC 2.2.1.11 - 6-deoxy-5-ketofructose 1-phosphate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.2.1.11
Names
Accepted name:
6-deoxy-5-ketofructose 1-phosphate synthase
Other
name:
DKFP synthase
Systematic name:
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphatetransferase
Reactions
- (1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
- (2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
Comments:
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
Links to other databases
UniProtKB/Swiss-Prot:
DKFP_METJA
References
-
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.Biochemistry 45 : 12366-12379 (2006). [PMID: 17014089]
-
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.FEMS Microbiol. Lett. 281 : 36-41 (2008). [PMID: 18318840]
[EC 2.2.1.11 created 2012]