EC - 6-deoxy-5-ketofructose 1-phosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
6-deoxy-5-ketofructose 1-phosphate synthase
Other name:
DKFP synthase
Systematic name:
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphatetransferase



The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC, fructose-bisphosphate aldolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. White, R. H., Xu, H.
    Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
    Biochemistry 45 : 12366-12379 (2006). [PMID: 17014089]
  2. Samland, A. K., Wang, M., Sprenger, G. A.
    MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
    FEMS Microbiol. Lett. 281 : 36-41 (2008). [PMID: 18318840]

[EC created 2012]