IntEnz

EC 2.2.1.1 - Transketolase

IntEnz Enzyme Nomenclature
EC 2.2.1.1

Names

Reactions

• 10508 [IUBMB]
  D-glyceraldehyde 3-phosphate

  D-glyceraldehyde 3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:59776

  Formula: C3H5O6P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-sedoheptulose 7-phosphate

  D-sedoheptulose 7-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57483

  Formula: C7H13O10P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  aldehydo-D-ribose 5-phosphate

  aldehydo-D-ribose 5-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58273

  Formula: C5H9O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-xylulose 5-phosphate

  D-xylulose 5-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57737

  Formula: C5H9O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  
• 27626
  D-erythrose 4-phosphate

  D-erythrose 4-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16897

  Formula: C4H7O7P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-xylulose 5-phosphate

  D-xylulose 5-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57737

  Formula: C5H9O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  β-D-fructose 6-phosphate

  beta-D-fructose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57634

  Formula: C6H11O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  D-glyceraldehyde 3-phosphate

  D-glyceraldehyde 3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:59776

  Formula: C3H5O6P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Cofactor

• thiamine diphosphate

Comments:

A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO₂ and R-CHOH-CO-CH₂OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

Links to other databases

References

1. de la Haba, G., Leder, I.G. and Racker, E.
   Crystalline transketolase from bakers' yeast: isolation and properties.
   J. Biol. Chem. 214: 409-426 (1955).
2. Domagk, G.F. and Horecker, B.L.
   Fructose and erythrose metabolism in Alcaligenes faecalis.
   Arch. Biochem. Biophys. 109: 342-349 (1965).
3. Horecker, B.L., Smyrniotis, P.Z. and Hurwitz, J.
   The role of xylulose 5-phosphate in the transketolase reaction.
   J. Biol. Chem. 223: 1009-1019 (1956).
4. Racker, E.
   Transketolase.
   In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 5, 1961, 397-412

[EC 2.2.1.1 created 1961]