EC 2 - Transferases
EC 2.2 - Transferring aldehyde or ketonic groups
EC 2.2.1 - Transketolases and transaldolases
EC 2.2.1.1 - Transketolase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.2.1.1
Names
Accepted name:
transketolase
Other
names:
glycolaldehydetransferase
glycoaldehyde transferase
glycoaldehyde transferase
Systematic name:
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Reaction
- sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor
Comments:
A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00635
Gene Ontology:
GO:0004802
CAS Registry Number:
9014-48-6
References
-
Crystalline transketolase from bakers' yeast: isolation and properties.J. Biol. Chem. 214 : 409-426 (1955).
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Fructose and erythrose metabolism in Alcaligenes faecalis.Arch. Biochem. Biophys. 109 : 342-349 (1965).
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The role of xylulose 5-phosphate in the transketolase reaction.J. Biol. Chem. 223 : 1009-1019 (1956).
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Transketolase.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 5 , 1961 , 397-412
[EC 2.2.1.1 created 1961]