EC 2.10.1.1 - Molybdopterin molybdotransferase

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IntEnz Enzyme Nomenclature
EC 2.10.1.1

Names

Accepted name:
molybdopterin molybdotransferase
Other names:
MoeA
Cnx1 [ambiguous]
Systematic name:
adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming)

Reaction

Cofactor

Comments:

Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin. In eukaryotes this reaction is catalysed by the N-terminal domain of a fusion protein whose C-terminal domain catalyses EC 2.7.7.75, molybdopterin adenylyltransferase. Requires divalent cations such as Mg2+ or Zn2+ for activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0061599
UniProtKB/Swiss-Prot: (26) [show] [UniProt]

References

  1. Nichols, J. D., Rajagopalan, K. V.
    In vitro molybdenum ligation to molybdopterin using purified components.
    J. Biol. Chem. 280: 7817-7822 (2005). [PMID: 15632135]
  2. Nichols, J. D., Xiang, S., Schindelin, H., Rajagopalan, K. V.
    Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft.
    Biochemistry 46: 78-86 (2007). [PMID: 17198377]
  3. Llamas, A., Otte, T., Multhaup, G., Mendel, R. R., Schwarz, G.
    The mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly.
    J. Biol. Chem. 281: 18343-18350 (2006). [PMID: 16636046]

[EC 2.10.1.1 created 2011]