EC 2 - Transferases
EC 2.1 - Transferring one-carbon groups
EC 2.1.3 - Carboxy- and carbamoyltransferases
EC 2.1.3.3 - Ornithine carbamoyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.1.3.3
Names
Accepted name:
ornithine carbamoyltransferase
Other
names:
L-ornithine carbamoyltransferase
L-ornithine carbamyltransferase
L-ornithine transcarbamylase
OTC
carbamylphosphate-ornithine transcarbamylase
citrulline phosphorylase
ornithine carbamyltransferase
ornithine transcarbamylase
L-ornithine carbamyltransferase
L-ornithine transcarbamylase
OTC
carbamylphosphate-ornithine transcarbamylase
citrulline phosphorylase
ornithine carbamyltransferase
ornithine transcarbamylase
Systematic name:
carbamoyl-phosphate:L-ornithine carbamoyltransferase
Reaction
-
19513 [IUBMB]carbamoyl phosphateName origin: UniProt - CHECKED (C)Formula: CH2NO5P
Charge: -2ChEBI compound status: CHECKED (C)L-ornithineName origin: UniProt - CHECKED (C)Formula: C5H13N2O2
Charge: 1ChEBI compound status: CHECKED (C)=H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)L-citrullineName origin: UniProt - CHECKED (C)Formula: C6H13N3O3
Charge: 0ChEBI compound status: CHECKED (C)
Comments:
The plant enzyme also catalyses the reactions of EC 2.1.3.6 putrescine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00091
Gene Ontology:
GO:0004585
CAS Registry Number:
9001-69-8
References
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Crystalline ornithine transcarbamylase.Biochim. Biophys. Acta 139 : 344-348 (1967).
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Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. I. Isolation and subunit structure.J. Biol. Chem. 247 : 1641-1653 (1972). [PMID: 4622303]
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Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics.J. Biol. Chem. 247 : 1654-1668 (1972). [PMID: 4622304]
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Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. 3. Effects of chemical modifications of specific residues on ligand binding and enzymatic activity.J. Biol. Chem. 247 : 1669-1682 (1972). [PMID: 4622305]
[EC 2.1.3.3 created 1961]