EC - Glycine hydroxymethyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
glycine hydroxymethyltransferase
Other names:
L-serine hydroxymethyltransferase
L-threonine aldolase
allothreonine aldolase
serine aldolase
serine hydroxymethylase
serine hydroxymethyltransferase
serine transhydroxymethylase
threonine aldolase
Systematic name:
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase




A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00090
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004372
CAS Registry Number: 9029-83-8
UniProtKB/Swiss-Prot: (804) [show] [UniProt]


  1. Akhtar, M. and El-Obeid, H.A.
    Inactivation of serine transhydroxymethylase and threonine aldolase activities.
    Biochim. Biophys. Acta 258 : 791-799 (1972). [PMID: 5017703]
  2. Blakley, R.L.
    A spectrophotometric study of the reaction catalysed by serine transhydroxymethylase.
    Biochem. J. 77 : 459-465 (1960).
  3. Fujioka, M.
    Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver.
    Biochim. Biophys. Acta 185 : 338-349 (1969). [PMID: 5808700]
  4. Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H.
    Threonine aldolase from Candida humicola. II. Purification, crystallization and properties.
    Biochim. Biophys. Acta 258 : 779-790 (1972). [PMID: 5017702]
  5. Schirch, L.V. and Gross, T.
    Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases.
    J. Biol. Chem. 243 : 5651-5655 (1968). [PMID: 5699057]

[EC created 1961, modified 1983]