EC - Methanol—corrinoid protein Co-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
methanol—corrinoid protein Co-methyltransferase
Other names:
MT 1 [ambiguous]
methanol cobalamin methyltransferase
methanol:5-hydroxybenzimidazolylcobamide methyltransferase
methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
mtaB (gene name)
Systematic name:
methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase



The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2]. Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047152
CAS Registry Number: 86611-98-5


  1. van der Meijden, P., te Brömmelstroet, B.W., Poirot, C.M., van der Drift, C. and Vogels, G.D.
    Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.
    J. Bacteriol. 160 : 629-635 (1984). [PMID: 6438059]
  2. Sauer, K., Thauer, R. K.
    Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
    Eur. J. Biochem. 261 : 674-681 (1999). [PMID: 10215883]

[EC created 1989, modified 2012]