EC 2.1.1.90 - Methanol—corrinoid protein Co-methyltransferase
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IntEnz Enzyme Nomenclature
EC 2.1.1.90
Names
Accepted name:
methanol—corrinoid protein Co-methyltransferase
Other
names:
MT 1
[ambiguous]
methanol cobalamin methyltransferase
methanol:5-hydroxybenzimidazolylcobamide methyltransferase
methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
mtaB (gene name)
methanol cobalamin methyltransferase
methanol:5-hydroxybenzimidazolylcobamide methyltransferase
methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
mtaB (gene name)
Systematic name:
methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction
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45204 [IUBMB][Co(I) methanol-specific corrinoid protein]GENERIC:11114Is ROOT: no
ROOT compound: GENERIC:11113Number of residues: 1H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)methanolName origin: UniProt - CHECKED (C)Formula: CH4O
Charge: 0ChEBI compound status: CHECKED (C)=[methyl-Co(III) methanol-specific corrinoid protein]GENERIC:11115Is ROOT: no
ROOT compound: GENERIC:11113Number of residues: 1
Comments:
The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2]. Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
Links to other databases
Gene Ontology:
GO:0047152
CAS Registry Number:
86611-98-5
UniProtKB/Swiss-Prot:
MTAB_METBF
References
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Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.J. Bacteriol. 160 : 629-635 (1984). [PMID: 6438059]
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Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.Eur. J. Biochem. 261 : 674-681 (1999). [PMID: 10215883]
[EC 2.1.1.90 created 1989, modified 2012]