EC - Cyclopropane-fatty-acyl-phospholipid synthase

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IntEnz Enzyme Nomenclature


Accepted name:
cyclopropane-fatty-acyl-phospholipid synthase
Other names:
CFA synthase
cyclopropane fatty acid synthase
cyclopropane fatty acid synthetase
cyclopropane synthase
cyclopropane synthetase
unsaturated-phospholipid methyltransferase
Systematic name:
S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)



The enzyme adds a methylene group across the 9,10 position of a Δ9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC methylene-fatty-acyl-phospholipid synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008825
CAS Registry Number: 51845-48-8
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Chung, A.E. and Law, J.H.
    Cyclopropane fatty acid synthetase: Partial purification and properties.
    Biochemistry 3 : 967-974 (1964).
  2. Zalkin, H., Law, J.H. and Goldfine, H.
    Enzymatic synthesis of cyclopropane fatty acids catalyzed by bacterial extracts.
    J. Biol. Chem. 238 : 1242-1248 (1963).

[EC created 1986]