EC - Caffeate O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
caffeate O-methyltransferase
Other names:
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
caffeate 3-O-methyltransferase
caffeate methyltransferase
Systematic name:
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase



3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047763
CAS Registry Number: 50936-45-3
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Ebel, J., Schaller-Hekeler, B., Knobloch, K.-H., Wellman, E., Grisebach, H. and Hahlbrock, K.
    Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.
    Biochim. Biophys. Acta 362 : 417-424 (1974). [PMID: 4472044]
  2. Poulton, J.E. and Butt, V.S.
    Purification and properties of S-adenosyl-L-methionine:caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
    Biochim. Biophys. Acta 403 : 301-314 (1975). [PMID: 241400]
  3. Shimada, M., Kuroda, H. and Higuchi, T.
    Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.
    Phytochemistry 12 : 2873-2875 (1973).

[EC created 1984]