EC 2.1.1.46 - Isoflavone 4'-O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.46

Names

Accepted name:
isoflavone 4'-O-methyltransferase
Other names:
4'-hydroxyisoflavone methyltransferase
isoflavone O-methyltransferase
isoflavone methyltransferase
Systematic name:
S-adenosyl-L-methionine:4'-hydroxyisoflavone 4'-O-methyltransferase

Reaction

Cofactor

Comments:

Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030746
CAS Registry Number: 55071-80-2
UniProtKB/Swiss-Prot:

References

  1. Wengenmayer, H., Ebel, J. and Grisebach, H.
    Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L.
    Eur. J. Biochem. 50: 135-143 (1974). [PMID: 4452353]

[EC 2.1.1.46 created 1976, modified 2011]