EC - Thymidylate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
thymidylate synthase
Other names:
TMP synthetase
dTMP synthase
methylenetetrahydrofolate:dUMP C-methyltransferase
thymidylate synthetase
Systematic name:
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00086
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004799
CAS Registry Number: 9031-61-2
UniProtKB/Swiss-Prot: (448) [show] [UniProt]


  1. Blakley, R.L.
    The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase.
    J. Biol. Chem. 238 : 2113-2118 (1963).
  2. Lockshin, A., Moran, R.G. and Danenberg, P.V.
    Thymidylate synthetase purified to homogeneity from human leukemic cells.
    Proc. Natl. Acad. Sci. USA 76 : 750-754 (1979). [PMID: 34155]
  3. Slavik, K. and Slavikova, V.
    Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography.
    Methods Enzymol. 66 : 709-723 (1980). [PMID: 6990200]
  4. Wahba, A.J. and Friedkin, M.
    The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli.
    J. Biol. Chem. 237 : 3794-3801 (1962).

[EC created 1976]