EC - Histone-lysine N-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
histone-lysine N-methyltransferase
Other names:
histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase
protein (lysine) methyltransferase
protein methylase 3
protein methylase III
protein methyltransferase II
protein-lysine N-methyltransferase
S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
Systematic name:
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase



One of a group of enzymes methylating proteins; see also EC cytochrome-c-lysine N-methyltransferase and EC calmodulin-lysine N-methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018024
CAS Registry Number: 9055-08-7
UniProtKB/Swiss-Prot: (263) [show] [UniProt]


  1. Paik, W.K. and Kim, S.
    Solubilization and partial purification of protein methylase 3 from calf thymus nuclei.
    J. Biol. Chem. 245: 6010-6015 (1970). [PMID: 5484460]
  2. Venkatesan, M. and McManus, I.R.
    Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum.
    Biochemistry 18: 5365-5371 (1979). [PMID: 391266]

[EC created 1976, modified 1982, modified 1983]