EC 2.1.1.372 - [histone H4]-lysine20 N-trimethyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.372

Names

Accepted name:
[histone H4]-lysine20 N-trimethyltransferase
Systematic name:
S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-trimethyltransferase

Reaction

Comments:

The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Sanders, S. L., Portoso, M., Mata, J., Bahler, J., Allshire, R. C., Kouzarides, T.
    Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
    Cell 119 : 603-614 (2004). [PMID: 15550243]

[EC 2.1.1.372 created 2020]