EC - 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
Systematic name:
S-adenosyl-L-methionine:3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase



This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Li, Y., Smolke, C. D.
    Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
    Nat Commun 7 : 12137 (2016). [PMID: 27378283]
  2. Park, M. R., Chen, X., Lang, D. E., Ng, K. K. S., Facchini, P. J.
    Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
    Plant J. 95 : 252-267 (2018). [PMID: 29723437]

[EC created 2018]