EC 2.1.1.349 - Toxoflavin synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.1.1.349

Names

Accepted name:
toxoflavin synthase
Other name:
toxA (gene name)
Systematic name:
S-adenosyl-L-methionine:1,6-didemethyltoxoflavin N1,N6-dimethyltransferase (toxoflavin-forming)

Reactions

Comments:

The enzyme is a dual-specificity methyltransferase that catalyses the last two steps of toxoflavin biosynthesis. Toxoflavin is a major virulence factor of several bacterial crop pathogens.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Fenwick, M. K., Philmus, B., Begley, T. P., Ealick, S. E.
    Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis.
    Biochemistry 55: 2748-2759 (2016). [PMID: 27070241]

[EC 2.1.1.349 created 2018]