EC - Toxoflavin synthase

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IntEnz Enzyme Nomenclature


Accepted name:
toxoflavin synthase
Other name:
toxA (gene name)
Systematic name:
S-adenosyl-L-methionine:1,6-didemethyltoxoflavin N1,N6-dimethyltransferase (toxoflavin-forming)



The enzyme is a dual-specificity methyltransferase that catalyses the last two steps of toxoflavin biosynthesis. Toxoflavin is a major virulence factor of several bacterial crop pathogens.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Fenwick, M. K., Philmus, B., Begley, T. P., Ealick, S. E.
    Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis.
    Biochemistry 55 : 2748-2759 (2016). [PMID: 27070241]

[EC created 2018]