EC - 8-amino-8-demethylriboflavin N,N-dimethyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
8-amino-8-demethylriboflavin N,N-dimethyltransferase
Other name:
rosA (gene name)
Systematic name:
S-adenosyl-L-methionine:8-amino-8-demethylriboflavin N,N-dimethyltransferase



The enzyme, characterized from the soil bacterium Streptomyces davawensis, catalyses the last two steps in the biosynthesis of the antibiotic roseoflavin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Jankowitsch, F., Kuhm, C., Kellner, R., Kalinowski, J., Pelzer, S., Macheroux, P., Mack, M.
    A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.
    J. Biol. Chem. 286 : 38275-38285 (2011). [PMID: 21911488]
  2. Tongsook, C., Uhl, M. K., Jankowitsch, F., Mack, M., Gruber, K., Macheroux, P.
    Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-D-riboflavin to the antibiotic roseoflavin.
    FEBS J. 283 : 1531-1549 (2016). [PMID: 26913589]

[EC created 2017]