IntEnz

EC 2.1.1.339 - Xanthohumol 4-O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.339

Names

Accepted name:

xanthohumol 4-O-methyltransferase

Other name:

OMT2 [ambiguous]

Systematic name:

S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase

Reaction

51704 [IUBMB]

S-adenosyl-L-methionine

S-adenosyl-L-methionine

Name origin: UniProt - CHECKED (C)

CHEBI:59789

Formula: C15H23N6O5S
Charge: 1

ChEBI compound status: CHECKED (C)

+

xanthohumol

xanthohumol

Name origin: UniProt - CHECKED (C)

CHEBI:134289

Formula: C21H21O5
Charge: -1

ChEBI compound status: CHECKED (C)

=

4-O-methylxanthohumol

4-O-methylxanthohumol

Name origin: UniProt - CHECKED (C)

CHEBI:139273

Formula: C22H23O5
Charge: -1

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-homocysteine

S-adenosyl-L-homocysteine

Name origin: UniProt - CHECKED (C)

CHEBI:57856

Formula: C14H20N6O5S
Charge: 0

ChEBI compound status: CHECKED (C)

Comments:

The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, chalconaringenin and isoliquiritigenin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

UniProtKB/Swiss-Prot:

B0ZB56

OMT2_HUMLU

References

Nagel, J., Culley, L. K., Lu, Y., Liu, E., Matthews, P. D., Stevens, J. F., Page, J. E.

EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol.

Plant Cell 20: 186-200 (2008). [PMID: 18223037]

[EC 2.1.1.339 created 2017, modified 2018]

EC 2 - Transferases