EC 188.8.131.527 - Reticuline N-methyltransferase
IntEnz Enzyme Nomenclature
- (1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine
- (2) S-adenosyl-L-methionine + (S)-corytuberine = S-adenosyl-L-homocysteine + magnoflorine
The enzyme from opium poppy (Papaver somniferum) can also methylate (R)-reticuline, tetrahydropapaverine, (S)-glaucine and (S)-bulbocapnine. It is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine.
Links to other databases
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.J. Biol. Chem. 291 : 23416-23427 (2016). [PMID: 27634038]
[EC 184.108.40.2067 created 2017]