EC - TRNA (guanine46-N7)-methyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
tRNA (guanine46-N7)-methyltransferase
Other names:
tRNA (m7G46) methyltransferase
transfer ribonucleate guanine 7-methyltransferase
7-methylguanine transfer ribonucleate methylase
tRNA guanine 7-methyltransferase
N7-methylguanine methylase
S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase
tRNA (m7G46)-methyltransferase
Systematic name:
S-adenosyl-L-methionine:tRNA (guanine-N7)-methyltransferase



The enzyme specifically methylates guanine46 at N7 in tRNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008176
CAS Registry Number: 37257-00-4
UniProtKB/Swiss-Prot: (557) [show] [UniProt]


  1. Aschhoff, H.J., Elten, H., Arnold, H.H., Mahal, G., Kersten, W. and Kersten, H.
    7-Methylguanine specific tRNA-methyltransferase from Escherichia coli.
    Nucleic Acids Res. 3: 3109-3122 (1976). [PMID: 794833]
  2. Zegers, I., Gigot, D., van Vliet, F., Tricot, C., Aymerich, S., Bujnicki, J. M., Kosinski, J., Droogmans, L.
    Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase.
    Nucleic Acids Res. 34: 1925-1934 (2006). [PMID: 16600901]
  3. Purta, E., van Vliet, F., Tricot, C., De Bie, L. G., Feder, M., Skowronek, K., Droogmans, L., Bujnicki, J. M.
    Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis.
    Proteins 59: 482-488 (2005). [PMID: 15789416]
  4. Liu, Q., Gao, Y., Yang, W., Zhou, H., Gao, Y., Zhang, X., Teng, M., Niu, L.
    Crystallization and preliminary crystallographic analysis of tRNA (m7G46) methyltransferase from Escherichia coli.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 743-745 (2008). [PMID: 18678947]
  5. Alexandrov, A., Martzen, M. R., Phizicky, E. M.
    Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
    RNA 8: 1253-1266 (2002). [PMID: 12403464]

[EC created 1972, modified 2011]