EC 2.1.1.300 - Pavine N-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.300

Names

Accepted name:
pavine N-methyltransferase
Other name:
PavNMT
Systematic name:
S-adenosyl-L-methionine:(±)-pavine N-methyltransferase

Reaction

Comments:

The enzyme, isolated from the plant Thalictrum flavum, also methylates (R,S)-stylopine and (S)-scoulerine (11%) with lower activity (14% and 11%, respectively). Formerly EC 2.1.1.n14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Jain, A., Ziegler, J., Liscombe, D. K., Facchini, P. J., Tucker, P. A., Panjikar, S.
    Purification, crystallization and X-ray diffraction analysis of pavine N-methyltransferase from Thalictrum flavum.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 : 1066-1069 (2008). [PMID: 18997344]
  2. Liscombe, D. K., Ziegler, J., Schmidt, J., Ammer, C., Facchini, P. J.
    Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species.
    Plant J. 60 : 729-743 (2009). [PMID: 19624470]

[EC 2.1.1.300 created 2014]