IntEnz - EC 2.1.1.261

EC 2 - Transferases

EC 2.1 - Transferring one-carbon groups

EC 2.1.1 - Methyltransferases

EC 2.1.1.261 - 4-dimethylallyltryptophan N-methyltransferase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.1.1.261

Names

Accepted name:

4-dimethylallyltryptophan N-methyltransferase

Other names:

fgaMT (gene name)
easF (gene name)

Systematic name:

S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase

Reaction

34435 [IUBMB]

4-(3-methylbut-2-enyl)-L-tryptophan

4-(3-methylbut-2-enyl)-L-tryptophan

Name origin: UniProt - CHECKED (C)

CHEBI:58209

Formula: C16H20N2O2
Charge: 0

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-methionine

S-adenosyl-L-methionine

Name origin: UniProt - CHECKED (C)

CHEBI:59789

Formula: C15H23N6O5S
Charge: 1

ChEBI compound status: CHECKED (C)

=

4-(3-methylbut-2-enyl)-L-abrine

4-(3-methylbut-2-enyl)-L-abrine

Name origin: UniProt - CHECKED (C)

CHEBI:67248

Formula: C17H22N2O2
Charge: 0

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-homocysteine

S-adenosyl-L-homocysteine

Name origin: UniProt - CHECKED (C)

CHEBI:57856

Formula: C14H20N6O5S
Charge: 0

ChEBI compound status: CHECKED (C)

Comments:

The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

Rigbers, O., Li, S. M.

Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.

J. Biol. Chem. 283: 26859-26868 (2008). [PMID: 18678866]

[EC 2.1.1.261 created 2012]