EC - Geranyl diphosphate 2-C-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
geranyl diphosphate 2-C-methyltransferase
Other names:
GPP methyltransferase
SCO7701 (gene name)
2-methyl-GPP synthase
geranyl pyrophosphate methyltransferase
Systematic name:
S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase




This enzyme, along with EC, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Wang, C. M., Cane, D. E.
    Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
    J. Am. Chem. Soc. 130 : 8908-8909 (2008). [PMID: 18563898]
  2. Ariyawutthiphan, O., Ose, T., Tsuda, M., Gao, Y., Yao, M., Minami, A., Oikawa, H., Tanaka, I.
    Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67 : 417-420 (2011). [PMID: 21393856]
  3. Komatsu, M., Tsuda, M., Omura, S., Oikawa, H., Ikeda, H.
    Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
    Proc. Natl. Acad. Sci. USA 105 : 7422-7427 (2008). [PMID: 18492804]
  4. Giglio, S., Chou, W. K., Ikeda, H., Cane, D. E., Monis, P. T.
    Biosynthesis of 2-methylisoborneol in cyanobacteria.
    Environ. Sci. Technol. 45 : 992-998 (2011). [PMID: 21174459]

[EC created 2012]