EC - Tetramethylammonium—corrinoid protein Co-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
tetramethylammonium—corrinoid protein Co-methyltransferase
Other names:
mtqB (gene name)
tetramethylammonium methyltransferase
Systematic name:
tetramethylammonium:5-hydroxybenzimidazolylcobamide Co-methyltransferase



The enzyme, which catalyses the transfer of a methyl group from tetramethylammonium to a tetramethylammonium-specific corrinoid protein (MtqC), is involved in methanogenesis from tetramethylammonium. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC, methylated tetramethylammonium-specific corrinoid protein:coenzyme M methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Asakawa, S., Sauer, K., Liesack, W., Thauer, R. K.
    Tetramethylammonium:coenzyme M methyltransferase system from methanococcoides sp.
    Arch. Microbiol. 170 : 220-226 (1998). [PMID: 9732435]

[EC created 2012]