EC - [trimethylamine—corrinoid protein] Co-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
[trimethylamine—corrinoid protein] Co-methyltransferase
Other names:
mttB (gene name)
trimethylamine methyltransferase
Systematic name:
trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase



The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043834
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Ferguson, D. J., Krzycki, J. A.
    Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
    J. Bacteriol. 179 : 846-852 (1997). [PMID: 9006042]
  2. Krzycki, J. A.
    Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
    Curr Opin Chem Biol 8 : 484-491 (2004). [PMID: 15450490]

[EC created 2012]