EC - 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
Other names:
cdhD (gene name)
cdhE (gene name)
Systematic name:
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase



Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC, carbon-monoxide dehydrogenase (ferredoxin) and EC, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Maupin-Furlow, J., Ferry, J. G.
    Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina thermophila.
    J. Bacteriol. 178 : 340-346 (1996). [PMID: 8550451]
  2. Grahame, D. A., DeMoll, E.
    Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.
    J. Biol. Chem. 271 : 8352-8358 (1996). [PMID: 8626532]

[EC created 2012]