EC 2.1.1.239 - L-olivosyl-oleandolide 3-O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.239

Names

Accepted name:
L-olivosyl-oleandolide 3-O-methyltransferase
Other name:
OleY
Systematic name:
S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase

Reaction

Comments:

The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Rodriguez, L., Rodriguez, D., Olano, C., Brana, A. F., Mendez, C., Salas, J. A.
    Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus.
    J. Bacteriol. 183: 5358-5363 (2001). [PMID: 11514520]

[EC 2.1.1.239 created 2012]