EC - 23S rRNA (adenosine1067-2'-O)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
23S rRNA (adenosine1067-2'-O)-methyltransferase
Other names:
23S rRNA A1067 2'-methyltransferase
thiostrepton-resistance methylase
nosiheptide-resistance methyltransferase
Systematic name:
S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase



The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030743


  1. Bechthold, A., Floss, H. G.
    Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.
    Eur. J. Biochem. 224 : 431-437 (1994). [PMID: 7925357]
  2. Thompson, J., Schmidt, F., Cundliffe, E.
    Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.
    J. Biol. Chem. 257 : 7915-7917 (1982). [PMID: 6806287]
  3. Thompson, J. and Cundliffe, E.
    Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton.
    J. Gen. Microbiol. 124 : 291-297 (1981).
  4. Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A. I., Xu, Y.
    Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus.
    Biochemistry 49 : 6440-6450 (2010). [PMID: 20550164]

[EC created 2011]