EC 2.1.1.229 - TRNA (carboxymethyluridine34-5-O)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.229

Names

Accepted name:
tRNA (carboxymethyluridine34-5-O)-methyltransferase
Other names:
ALKBH8
ABH8
Trm9
tRNA methyltransferase 9
Systematic name:
S-adenosyl-L-methionine:tRNA (carboxymethyluridine34-5-O)-methyltransferase

Reaction

Comments:

The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0106335
UniProtKB/Swiss-Prot: (13) [show] [UniProt]

References

  1. Fu, D., Brophy, J. A., Chan, C. T., Atmore, K. A., Begley, U., Paules, R. S., Dedon, P. C., Begley, T. J., Samson, L. D.
    Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.
    Mol. Cell. Biol. 30 : 2449-2459 (2010). [PMID: 20308323]
  2. Songe-Møller, L., van den Born, E., Leihne, V., Vågbø, C. B., Kristoffersen, T., Krokan, H. E., Kirpekar, F., Falnes, P. Ø., Klungland, A.
    Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
    Mol. Cell. Biol. 30 : 1814-1827 (2010). [PMID: 20123966]
  3. Kalhor, H. R., Clarke, S.
    Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
    Mol. Cell. Biol. 23 : 9283-9292 (2003). [PMID: 14645538]

[EC 2.1.1.229 created 2011]