EC 2.1.1.221 - TRNA (guanine9-N1)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.221

Names

Accepted name:
tRNA (guanine9-N1)-methyltransferase
Other names:
tRNA(m1G9/m1A9)-methyltransferase
tRNA(m1G9/m1A9)MTase
tRNA (guanine-N(1)-)-methyltransferase
Trm10p [ambiguous]
tRNA m1G9-methyltransferase
tRNA m1G9 MTase
Systematic name:
S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase

Reaction

Comments:

The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052905
UniProtKB/Swiss-Prot: (34) [show] [UniProt]

References

  1. Kempenaers, M., Roovers, M., Oudjama, Y., Tkaczuk, K. L., Bujnicki, J. M., Droogmans, L.
    New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
    Nucleic Acids Res. 38 : 6533-6543 (2010). [PMID: 20525789]
  2. Jackman, J. E., Montange, R. K., Malik, H. S., Phizicky, E. M.
    Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.
    RNA 9 : 574-585 (2003). [PMID: 12702816]

[EC 2.1.1.221, created 1972 as EC 2.1.1.31, part-transferred 2011 to EC 2.1.1.221]