EC 2.1.1.218 - TRNA (adenine9-N1)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.218

Names

Accepted name:
tRNA (adenine9-N1)-methyltransferase
Other names:
Trm10p [ambiguous]
tRNA(m1G9/m1A9)-methyltransferase
tRNA(m1G9/m1A9)MTase
TK0422p
tRNA m1A9-methyltransferase
tRNA m1A9 Mtase
Systematic name:
S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase

Reaction

Comments:

The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kempenaers, M., Roovers, M., Oudjama, Y., Tkaczuk, K. L., Bujnicki, J. M., Droogmans, L.
    New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
    Nucleic Acids Res. 38 : 6533-6543 (2010). [PMID: 20525789]

[EC 2.1.1.218 created 1972 as EC 2.1.1.36, part-transferred 2011 to EC 2.1.1.218]