EC - Demethylspheroidene O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
demethylspheroidene O-methyltransferase
Other names:
1-hydroxycarotenoid O-methylase
1-hydroxycarotenoid methylase
1-HO-carotenoid methylase
Systematic name:
S-adenosyl-L-methionine:demethylspheroidene O-methyltransferase



In Rhodopseudomonas capsulata and Rubrivivax gelatinosus the enzyme is involved in biosynthesis of spheroidene [1,2,3]. In Rubrivivax gelatinosus the enzyme also catalyses the methylation of demethylspirilloxanthin to spirilloxanthin and the methylation of 3,4-didehydrorhodopin to anhydrorhodovibrin [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043803


  1. Badenhop, F., Steiger, S., Sandmann, M., Sandmann, G.
    Expression and biochemical characterization of the 1-HO-carotenoid methylase CrtF from Rhodobacter capsulatus.
    FEMS Microbiol. Lett. 222 : 237-242 (2003). [PMID: 12770713]
  2. Pinta, V., Ouchane, S., Picaud, M., Takaichi, S., Astier, C., Reiss-Husson, F.
    Characterization of unusual hydroxy- and ketocarotenoids in Rubrivivax gelatinosus: involvement of enzyme CrtF or CrtA.
    Arch. Microbiol. 179 : 354-362 (2003). [PMID: 12664193]
  3. Scolnik, P. A., Walker, M. A., Marrs, B. L.
    Biosynthesis of carotenoids derived from neurosporene in Rhodopseudomonas capsulata.
    J. Biol. Chem. 255 : 2427-2432 (1980). [PMID: 7358679]

[EC created 2011]