EC - 23S rRNA (guanine2535-N1)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
23S rRNA (guanine2535-N1)-methyltransferase
Other name:
Systematic name:
S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase



Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine2535-N1)-methyltransferase and EC [23S rRNA (uridine2479-2-O)-methyltransferase], whose actions confer avilamycin resistance to the RNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Treede, I., Jakobsen, L., Kirpekar, F., Vester, B., Weitnauer, G., Bechthold, A., Douthwaite, S.
    The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.
    Mol. Microbiol. 49 : 309-318 (2003). [PMID: 12828631]
  2. Weitnauer, G., Gaisser, S., Trefzer, A., Stockert, S., Westrich, L., Quiros, L. M., Mendez, C., Salas, J. A., Bechthold, A.
    An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
    Antimicrob. Agents Chemother. 45 : 690-695 (2001). [PMID: 11181344]
  3. Mosbacher, T. G., Bechthold, A., Schulz, G. E.
    Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.
    J. Mol. Biol. 329 : 147-157 (2003). [PMID: 12742024]

[EC created 2011]