EC 2.1.1.208 - 23S rRNA (uridine2479-2'-O)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.208

Names

Accepted name:
23S rRNA (uridine2479-2'-O)-methyltransferase
Other name:
AviRb
Systematic name:
S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase

Reaction

Comments:

Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Mosbacher, T. G., Bechthold, A., Schulz, G. E.
    Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
    J. Mol. Biol. 345: 535-545 (2005). [PMID: 15581897]
  2. Treede, I., Jakobsen, L., Kirpekar, F., Vester, B., Weitnauer, G., Bechthold, A., Douthwaite, S.
    The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.
    Mol. Microbiol. 49: 309-318 (2003). [PMID: 12828631]
  3. Weitnauer, G., Gaisser, S., Trefzer, A., Stockert, S., Westrich, L., Quiros, L. M., Mendez, C., Salas, J. A., Bechthold, A.
    An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
    Antimicrob. Agents Chemother. 45: 690-695 (2001). [PMID: 11181344]

[EC 2.1.1.208 created 2011]