EC - TRNA (cytosine38-C5)-methyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
tRNA (cytosine38-C5)-methyltransferase
Other names:
hDNMT2 (gene name)
DNMT2 (gene name)
TRDMT1 (gene name)
Systematic name:
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase



The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00089
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C. L., Zhang, X., Golic, K. G., Jacobsen, S. E., Bestor, T. H.
    Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
    Science 311 : 395-398 (2006). [PMID: 16424344]
  2. Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G., Jeltsch, A.
    Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism.
    RNA 14 : 1663-1670 (2008). [PMID: 18567810]
  3. Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., Lyko, F.
    RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
    Genes Dev. 24 : 1590-1595 (2010). [PMID: 20679393]

[EC created 2011]