EC - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

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IntEnz Enzyme Nomenclature


Accepted name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Other name:
ubiE (gene name) [ambiguous]
Systematic name:
S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase



This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant [3]. The bifunctional enzyme from E. coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00911
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043333
UniProtKB/Swiss-Prot: (285) [show] [UniProt]


  1. Lee, P. T., Hsu, A. Y., Ha, H. T., Clarke, C. F.
    A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
    J. Bacteriol. 179 : 1748-1754 (1997). [PMID: 9045837]
  2. Young, I. G., McCann, L. M., Stroobant, P., Gibson, F.
    Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone.
    J. Bacteriol. 105 : 769-778 (1971). [PMID: 4323297]
  3. Dibrov, E., Robinson, K. M., Lemire, B. D.
    The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain.
    J. Biol. Chem. 272 : 9175-9181 (1997). [PMID: 9083048]
  4. Barkovich, R. J., Shtanko, A., Shepherd, J. A., Lee, P. T., Myles, D. C., Tzagoloff, A., Clarke, C. F.
    Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis.
    J. Biol. Chem. 272 : 9182-9188 (1997). [PMID: 9083049]

[EC created 2011]