EC 2.1.1.196 - Cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]

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IntEnz Enzyme Nomenclature
EC 2.1.1.196

Names

Accepted name:
cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
Other names:
cobalt-precorrin-6Y (C15)-methyltransferase [decarboxylating]
cbiT (gene name)
S-adenosyl-L-methionine:precorrin-7 C15-methyltransferase (C-12-decarboxylating)
cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating]
Systematic name:
S-adenosyl-L-methionine:precorrin-6B C15-methyltransferase (C-12-decarboxylating)

Reaction

Comments:

This enzyme catalyses both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (28) [show] [UniProt]

References

  1. Keller, J. P., Smith, P. M., Benach, J., Christendat, D., deTitta, G. T., Hunt, J. F.
    The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase.
    Structure 10: 1475-1487 (2002). [PMID: 12429089]
  2. Santander, P. J., Kajiwara, Y., Williams, H. J., Scott, A. I.
    Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway.
    Bioorg. Med. Chem. 14: 724-731 (2006). [PMID: 16198574]
  3. Moore, S. J., Lawrence, A. D., Biedendieck, R., Deery, E., Frank, S., Howard, M. J., Rigby, S. E., Warren, M. J.
    Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
    Proc. Natl. Acad. Sci. U.S.A. 110: 14906-14911 (2013). [PMID: 23922391]

[EC 2.1.1.196 created 2010, modified 2013]