EC 2.1.1.180 - 16S rRNA (adenine1408-N1)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.180

Names

Accepted name:
16S rRNA (adenine1408-N1)-methyltransferase
Other names:
kanamycin-apramycin resistance methylase
16S rRNA:m1A1408 methyltransferase
KamB
NpmA
16S rRNA m1A1408 methyltransferase
Systematic name:
S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase

Reaction

Comments:

The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Beauclerk, A. A., Cundliffe, E.
    Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.
    J. Mol. Biol. 193: 661-671 (1987). [PMID: 2441068]
  2. Koscinski, L., Feder, M., Bujnicki, J. M.
    Identification of a missing sequence and functionally important residues of 16S rRNA:m1A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics.
    Cell Cycle 6: 1268-1271 (2007). [PMID: 17495534]
  3. Holmes, D. J., Drocourt, D., Tiraby, G., Cundliffe, E.
    Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius.
    Gene 102: 19-26 (1991). [PMID: 1840536]
  4. Wachino, J., Shibayama, K., Kurokawa, H., Kimura, K., Yamane, K., Suzuki, S., Shibata, N., Ike, Y., Arakawa, Y.
    Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
    Antimicrob. Agents Chemother. 51: 4401-4409 (2007). [PMID: 17875999]

[EC 2.1.1.180 created 2010]